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ea0029p351 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Familial central diabetes insipidus due to a novel mutation in exon 3 of the arginine vasopressin gene

Ritter M. , Gross U. , Feldkamp J. , Hoppner W. , Schulte H.

Neurohypophyseal diabetes insipidus (DI) is said to be caused by familial forms in about 5% of cases1. Hereditary transmission is autosomal dominant in most families and is caused by a mutation in the arginine vasopressin (AVP) gene on chromosome 20p13, which encodes for a large precursor hormone.A 19-years old otherwise healthy patient seeked endocrine care for an inadequately treated DI. He reported about an undoubtful disease history with a...

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ea0029p1458 | Pituitary Clinical | ICEECE2012

Pitfalls in Cushing’s disease: report of an ectopic ACTH-producing pituitary adenoma in the sphenoid sinus

Ritter M. , Burkhardt T. , Schmid S. , Bernreuther C. , Winterberg B. , Lehnert H. , Flitsch J.

Cushings disease is caused by ACTH-secreting pituitary adenomas. Gold standard therapy is the resection of the adenoma by transsphenoidal surgery with high cure rates even in cases of negative MR imaging. Surgical failure despite clear endocrinological test results is possible and mostly explained by hidden minute adenomas within the gland.We report on a 50-year-old woman suffering from ACTH-dependent Cushings syndrome. Endocrinological work-...

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Endocrine Abstracts

Familial central diabetes insipidus due to a novel mutation in exon 3 of the arginine vasopressin gene

Pitfalls in Cushing’s disease: report of an ectopic ACTH-producing pituitary adenoma in the sphenoid sinus

BiosciAbstracts